Article
Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells.
Journal of medicinal chemistry - 26 Oct 2017
Endo Satoshi, Xia Shuang, Suyama Miho, Morikawa Yoshifumi, Oguri Hiroaki, Hu Dawei, Ao Yoshinori, Takahara Satoyuki, Horino Yoshikazu, Hayakawa Yoshihiro, Watanabe Yurie, Gouda Hiroaki, Hara Akira, Kuwata Kazuo, Toyooka Naoki, Matsunaga Toshiyuki, Ikari Akira
Abstract excerpt
Aldo-keto reductase 1B10 (AKR1B10) is overexpressed in several extraintestinal cancers, particularly in non-small-cell lung cancer, where AKR1B10 is a potential diagnostic marker and therapeutic target. Selective AKR1B10 inhibitors are required because compounds should not inhibit the highly related aldose reductase that is involved in monosaccharide and prostaglandin metabolism. Currently,...
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