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Article

Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.

Journal of natural products - 27 May 2011

Takemura Mayuko, Endo Satoshi, Matsunaga Toshiyuki, Soda Midori, Zhao Hai-Tao, El-Kabbani Ossama, Tajima Kazuo, Iinuma Munekazu, Hara Akira

Abstract excerpt

A human member of the aldo-keto reductase (AKR) superfamily, AKR1B10, was recently suggested as a therapeutic target in the treatment of several types of cancer. Due to its high sequence identity with human aldose reductase (AKR1B1), selective inhibition of AKR1B10 compared with AKR1B1 is required for the development of anticancer agents. In this study, we have examined AKR1B10 inhibition by seven pentacyclic...

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PMID: 21561086
DOI: 10.1021/np200118q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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