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Article

ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.

Human molecular genetics - 1 Aug 2010

Pedrini Steve, Sau Daniela, Guareschi Stefania, Bogush Marina, Brown Robert H, Naniche Nicole, Kia Azadeh, Trotti Davide, Pasinelli Piera

Abstract excerpt

In mutant superoxide dismutase (SOD1)-linked amyotrophic lateral sclerosis (ALS), accumulation of misfolded mutant SOD1 in spinal cord mitochondria is thought to cause mitochondrial dysfunction. Whether mutant SOD1 is toxic per se or whether it damages the mitochondria through interactions with o...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

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Share to Protein Structure, Tertiary

Share to Proto-Oncogene Proteins c-bcl-2

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Source

Open in PubMed Open full text

Identifiers

PMID: 20460269
DOI: 10.1093/hmg/ddq202
PMCID: PMC2901139

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20460269-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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