Article
Mitochondrial involvement in amyotrophic lateral sclerosis: trigger or target?
Molecular neurobiology - 1 Apr 2006
Bacman Sandra R, Bradley Walter G, Moraes Carlos T
Abstract excerpt
Despite numerous reports demonstrating mitochondrial abnormalities associated with amyotrophic lateral sclerosis (ALS), the role of mitochondrial dysfunction in the disease onset and progression remains unknown. The intrinsic mitochondrial apoptotic program is activated in the central nervous system of mouse models of ALS harboring mutant superoxide dismutase 1 protein. This is associated with the release of...
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