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Article

Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal Cell Death.

Molecular neurobiology - 1 Jan 2023

Kook Myung Geun, Byun Mi Ran, Lee Soo Min, Lee Min Hak, Lee Dae Hoon, Lee Hyung Been, Lee Eui-Jin, Baek Kyunghwa, Kim Sunghoon, Kang Kyung-Sun, Choi Jin Woo

Abstract excerpt

Although a couple of studies have reported that mutant superoxide dismutase 1 (SOD1), one of the causative genes of familial amyotrophic lateral, interacts physically with lysyl-tRNA synthetase (KARS1) by a gain of function, there is limited evidence regarding the detailed mechanism about how the interaction leads to neuronal cell death. Our results indicated that the aminoacyl-tRNA synthetase-interacting...

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PMID: 36242734
DOI: 10.1007/s12035-022-03073-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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