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Article

Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria.

The Journal of biological chemistry - 17 Oct 2008

Kawamata Hibiki, Magrané Jordi, Kunst Catherine, King Michael P, Manfredi Giovanni

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting the motor neurons. The majority of familial forms of ALS are caused by mutations in the Cu,Zn-superoxide dismutase (SOD1). In mutant SOD1 spinal cord motor neurons, mitochondria develop abnormal morphology, bioenergetic defects, and degeneration. However, the mechanisms of mitochondrial toxicity are still unclear. One...

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Identifiers

PMID: 18715867
DOI: 10.1074/jbc.M805599200
PMCID: PMC2568925

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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