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Article

Drosophila GFAT1 and GFAT2 enzymes encode obligate developmental functions.

Fly - 1 Jan 2000

Chen Po, Visokay Sarah, Abrams John M

Abstract excerpt

Glutamine: fructose-6-phosphate amidotransferase (GFAT) enzymes catalyse the first committed step of the hexosamine biosynthesis pathway (HBP) using glutamine and fructose-6-phosphate to form glucosamine-6-phosphate (GlcN6P). Numerous species (e.g. mouse, rat, zebrafish, chicken) including humans and Drosophila encode two broadly expressed copies of this enzyme but whether these perform redundant, partially...

Topics

Alleles
Amino Acid Sequence
Animals
CRISPR-Cas Systems
Dietary Supplements
Drosophila Proteins
Gene Expression Regulation, Developmental
Gene Expression Regulation, Enzymologic
Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
Larva

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Identifiers

PMID: 32615907
DOI: 10.1080/19336934.2020.1784674
PMCID: PMC7714458

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