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Mgat1-dependent N-glycans are essential for the normal development of both vertebrate and invertebrate metazoans.

Seminars in cell & developmental biology - 1 Aug 2010

Schachter Harry

Abstract excerpt

UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I (GnTI, encoded by Mgat1) first appeared in evolution at about the same time as metazoa suggesting that GnTI-dependent glycans are essential for the development of multicellular organisms. This review describes the effects of mutations in the Mgat1 gene on the development of Caenorhabditis elegans, Drosophila melanogaster and mice.

Topics

Acyltransferases
Animals
Caenorhabditis elegans
Carbohydrate Conformation
Carbohydrate Sequence
Drosophila melanogaster
Humans
Mice
Molecular Sequence Data
Morphogenesis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

N-Acetylglucosaminyltransferases

Phosphorylcholine

Polysaccharides

Source

Identifiers

PMID: 20206280
DOI: 10.1016/j.semcdb.2010.02.010

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