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Article

Genetic and maternal effects on valproic acid teratogenesis in C57BL/6J and DBA/2J mice.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Aug 2010

Downing Chris, Biers Jami, Larson Colin, Kimball Alexi, Wright Hali, Ishii Takamasa, Gilliam David, Johnson Thomas

Abstract excerpt

Valproic acid (VPA) is used worldwide to treat epilepsy, migraine headaches, and bipolar disorder. However, VPA is teratogenic and in utero exposure can lead to congenital malformations. Using inbred C57BL/6J (B6) and DBA/2J (D2) mice, we asked whether genetic variation could play a role in susceptibility to VPA teratogenesis. Whereas B6 fetuses were more susceptible than D2 fetuses to digit and vertebral...

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Identifiers

PMID: 20457659
DOI: 10.1093/toxsci/kfq140
PMCID: PMC2905403

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Source receipt: pubmed, retrieved 7 Sept 2026.

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