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Article

Adverse effects of valproate on bone: defining a model to investigate the pathophysiology.

Epilepsia - 1 Jun 2010

Senn Susan M, Kantor Susan, Poulton Ingrid J, Morris Margaret J, Sims Natalie A, O'Brien Terence J, Wark John D

Abstract excerpt

PURPOSE: Bone disease and fractures are common with chronic antiepileptic drug (AED) therapy, but the underlying mechanisms are poorly understood. This study aimed to characterize adverse bone effects of valproate and to identify mouse strains either resistant or sensitive to these effects. METHODS: Seven mouse strains (n = 40/strain; 10/diet) were screened for the effect of chronic (8 weeks) valproate treatment...

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Source

Identifiers

PMID: 20163440
DOI: 10.1111/j.1528-1167.2009.02516.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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