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Article

Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2010

Freiberg J J, Tybjaerg-Hansen A, Nordestgaard B G

Abstract excerpt

BACKGROUND: Atherosclerosis is an inflammatory condition where cysteinyl leukotrienes have been identified to play an important role. Furthermore, cysteinyl leukotrienes may also affect thrombus formation. Using prospective, cross-sectional and case-control designs, we tested the hypothesis that hitherto unknown genetic variation, likely to affect the function of leukotriene C(4) synthase, is associated with risk...

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PMID: 20456754
DOI: 10.1111/j.1538-7836.2010.03903.x

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