Article
Genetically Mediated Differences in LDL Cholesterol and Risk of Venous Thromboembolism.
Journal of the American College of Cardiology - 8 Sept 2026
Sui Yang, Kany Shinwan, Khurshid Shaan, Supriami Kelvin, Rämö Joel T, Jurgens Sean J, Enzan Nobuyuki, Choi Seung Hoan, Yu Zhi, Li Linke, Truong Buu, Chen Xingyu, Kim Min Seo, Shim Injeong, Twerenbold Raphael, Pirruccello James P, Natarajan Pradeep, Ellinor Patrick T, Fahed Akl C
Abstract excerpt
BACKGROUND: Venous thromboembolism (VTE) is a common and clinically significant cardiovascular condition. Although low-density lipoprotein (LDL) cholesterol is causally linked to atherosclerotic disease, its role in VTE remains unclear. Meta-analyses of randomized trials have suggested modest reductions in VTE with lipid-lowering therapy, but whether these effects are LDL mediated is uncertain. OBJECTIVES: This...
Read the complete abstract on PubMedTopics
- Humans
- Venous Thromboembolism
- Cholesterol, LDL
- Proprotein Convertase 9
- Female