Article
Molecular subtyping of tumors from patients with familial glioma.
Neuro-oncology - 18 May 2018
Ruiz Vanessa Y, Praska Corinne E, Armstrong Georgina, Kollmeyer Thomas M, Yamada Seiji, Decker Paul A, Kosel Matthew L, Eckel-Passow Jeanette E, Lachance Daniel H, Bainbridge Matthew N, Melin Beatrice S, Bondy Melissa L, Jenkins Robert B
Abstract excerpt
Background: Single-gene mutation syndromes account for some familial glioma (FG); however, they make up only a small fraction of glioma families. Gliomas can be classified into 3 major molecular subtypes based on isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion. We hypothesized that the prevalence of molecular subtypes might differ in familial versus sporadic gliomas and that tumors in the same...
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