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Article

Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number.

PloS one - 3 May 2010

Pohjoismäki Jaakko L O, Goffart Steffi, Taylor Robert W, Turnbull Douglas M, Suomalainen Anu, Jacobs Howard T, Karhunen Pekka J

Abstract excerpt

Adult human heart mitochondrial DNA (mtDNA) has recently been shown to have a complex organization with abundant dimeric molecules, branched structures and four-way junctions. In order to understand the physiological significance of the heart-specific mtDNA maintenance mode and to find conditions that modify human heart mtDNA structure and replication, we analyzed healthy human heart of various ages as well as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20454654
DOI: 10.1371/journal.pone.0010426
PMCID: PMC2862702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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