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Article

Detection of heterozygous mutations in the genome of mismatch repair defective diploid yeast using a Bayesian approach.

Genetics - 1 Oct 2010

Zanders Sarah, Ma Xin, Roychoudhury Arindam, Hernandez Ryan D, Demogines Ann, Barker Brandon, Gu Zhenglong, Bustamante Carlos D, Alani Eric

Abstract excerpt

DNA replication errors that escape polymerase proofreading and mismatch repair (MMR) can lead to base substitution and frameshift mutations. Such mutations can disrupt gene function, reduce fitness, and promote diseases such as cancer and are also the raw material of molecular evolution. To analyze with limited bias genomic features associated with DNA polymerase errors, we performed a genome-wide analysis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20660644
DOI: 10.1534/genetics.110.120105
PMCID: PMC2954485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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