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Maternal protein restriction in rats leads to reduced PGC-1α expression via altered DNA methylation in skeletal muscle

19 Oct 2012

Abstract excerpt

Intrauterine growth retardation (IUGR) is thought to program insulin resistance, type 2 diabetes and other metabolic diseases in later life. Skeletal muscle is an important tissue involved in regulating the metabolism. We therefore hypothesized that the regulation of glucose- and lipid-related genes in skeletal muscle may contribute to metabolic changes in rats with IUGR. In this study, IUGR rats were bred from...

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Identifiers

PMID: 23117952
DOI: 10.3892/mmr.2012.1134

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