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Deoxyribonucleic Acid Methylation and Gene Expression of PPARGC1A in Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent Manner

22 Apr 2010

Abstract excerpt

CONTEXT: Low birth weight (LBW) and unhealthy diets are risk factors of metabolic disease including type 2 diabetes (T2D). Genetic, nongenetic, and epigenetic data propose a role of the key metabolic regulator peroxisome proliferator-activated receptor gamma, coactivator 1alpha (PPARGC1A) in the development of T2D. OBJECTIVE: Our objective was to investigate gene expression and DNA methylation of PPARGC1A and...

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Identifiers

PMID: 20410232
DOI: 10.1210/jc.2009-2413

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