Interleukin 7 receptor alpha Thr244Ile genetic polymorphism is associated with susceptibility and prognostic markers in breast cancer subgroups.

doi:10.1016/j.cyto.2017.09.019

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Article

Interleukin 7 receptor alpha Thr244Ile genetic polymorphism is associated with susceptibility and prognostic markers in breast cancer subgroups.

Cytokine - 1 Mar 2018

Vitiello Glauco Akelinghton Freire, Losi Guembarovski Roberta, Amarante Marla Karine, Ceribelli Jesus Roberto, Carmelo Elaine Cristina Baraldi, Watanabe Maria Angelica Ehara

Abstract excerpt

Interleukin-7 (IL-7) exerts crucial functions on lymphoid cells' development and maintenance. In breast cancer (BC), IL-7 promotes growth of tumor cells in culture through the activation of JAK1/3-STAT5 and PI3K/AKT pathways, and expression of IL-7 signaling components was associated with worst prognosis. AC>T polymorphism (rs6897932; Thr244Ile) at exon 6 of IL-7 receptor alpha (IL-7Rα) gene (IL7RA) shifts the...

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PMID: 28964592
DOI: 10.1016/j.cyto.2017.09.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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