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Article

A -1573T>C SNP within the human TRAIL promoter determines TRAIL expression and HCC tumor progression.

Cancer medicine - 1 Oct 2016

Piras-Straub Katja, Khairzada Khaleda, Kocabayoglu Peri, Paul Andreas, Gerken Guido, Herzer Kerstin

Abstract excerpt

The cytokine tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in liver cancer cells but not in normal liver cells. Therefore, TRAIL got credited to play a role in hepatocellular carcinoma (HCC) development and progression. Impaired expression of TRAIL in HCC cells and sequence variations in the TRAIL promoter may facilitate development, growth, and spread . The TRAIL...

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Share to Carcinoma, Hepatocellular
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hep G2 Cells

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Share to Promoter Regions, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 27580702
DOI: 10.1002/cam4.854
PMCID: PMC5083748

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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