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Article

Occult infection of peripheral B cells by hepatitis C variants which have low translational efficiency in cultured hepatocytes.

Gut - 1 Jul 2010

Durand Tony, Di Liberto Gaëtana, Colman Hélène, Cammas Anne, Boni Sebastien, Marcellin Patrick, Cahour Annie, Vagner Stephan, Féray Cyrille

Abstract excerpt

BACKGROUND: Plasma hepatitis C virus (HCV) originates from hepatocytes. However, in certain subjects, B cells may harbour both plasma strains and occult HCV strains tha t are not detected in the plasma. The internal ribosome entry site (IRES) of these latter strains is mutated, suggesting that the efficiency of viral translation could drive the cellular tropism of HCV. AIMS: To determine if the translational...

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Identifiers

PMID: 20442199
DOI: 10.1136/gut.2009.192088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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