Evidence for depletion of CASP5 Ala90Thr heterozygous genotype in aged subjects.

doi:10.1016/j.exger.2010.04.007

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Evidence for depletion of CASP5 Ala90Thr heterozygous genotype in aged subjects.

Experimental gerontology - 1 Sept 2010

Ulybina Yulia M, Kuligina Ekatherina Sh, Mitiushkina Nathalia V, Sherina Nathalia Yu, Yanus Grigoriy A, Gorodnova Tatiana V, Katanugina Anna S, Koloskov Andrey V, Togo Alexandr V, Imyanitov Evgeny N

Abstract excerpt

Our previous studies, which included genotyping of multiple coding apoptotic gene polymorphisms, unexpectedly demonstrated a depletion of heterozygous CASP5 Ala90Thr (rs507879, c.268 G>A) genotypes in elderly subjects. Present investigation was aimed to validate this trend. An analysis of 510 subjects aged 75-103years revealed 205 (40%) CASP5 Ala90Thr heterozygotes as compared to 254 (50%) expected from the minor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Neoplasms

Share to Smoking

Source

Open in PubMed

Identifiers

PMID: 20434535
DOI: 10.1016/j.exger.2010.04.007

Genes

CASP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Evidence for depletion of CASP5 Ala90Thr heterozygous genotype in aged subjects.PMID 20434535Read ↗

Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer.Semantic proximity Read ↗

Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.Semantic proximity Read ↗

Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals.Semantic proximity Read ↗

The tumor necrosis factor alpha -308G>A polymorphism is associated with dementia in the oldest old.Semantic proximity Read ↗

Gender-specific association of ADA genetic polymorphism with human longevity.Semantic proximity Read ↗

Caspase-1 genetic variation is not associated with Alzheimer's disease risk.Semantic proximity Read ↗

Homozygous MHC genotypes and longevity.Semantic proximity Read ↗

Association between the polymorphism of CCR5 and Alzheimer's disease: results of a study performed on male and female patients from Northern Italy.Semantic proximity Read ↗

The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death.Semantic proximity Read ↗

[Association of polymorphic markers of CASP8, BCL2 and BAX genes with aging and longevity].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.