Article
No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression.
Biological psychiatry - 1 Jul 2010
Tost Heike, Lipska Barbara K, Vakkalanka Radhakrishna, Lemaitre Herve, Callicott Joseph H, Mattay Venkata S, Kleinman Joel E, Marenco Stefano, Weinberger Daniel R
Abstract excerpt
BACKGROUND: A recent genome-wide association study linked a common variant in RELN (rs7341475G) with risk for schizophrenia in women. In the largest neuroimaging intermediate phenotype study reported so far, we evaluated the effect of rs7341475 on an extended array of different neuroscientific measures. METHODS: Brain structure was evaluated with voxel-based morphometry and diffusion tensor imaging. Brain...
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