Article
Sex-specific association of the Reelin gene with bipolar disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2010
Goes F S, Willour V L, Zandi P P, Belmonte P L, MacKinnon D F, Mondimore F M, Schweizer B, DePaulo J R, Gershon E S, McMahon F J, Potash J B
Abstract excerpt
The Reelin gene (RELN) encodes a secretory glycoprotein critical for brain development and synaptic plasticity. Post-mortem studies have shown lower Reelin protein levels in the brains of patients with schizophrenia and bipolar disorder (BP) compared with controls. In a recent genome-wide association study of schizophrenia, the strongest association was found in a marker within RELN, although this association was...
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