Article
Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women.
PLoS genetics - 1 Feb 2008
Shifman Sagiv, Johannesson Martina, Bronstein Michal, Chen Sam X, Collier David A, Craddock Nicholas J, Kendler Kenneth S, Li Tao, O'Donovan Michael, O'Neill F Anthony, Owen Michael J, Walsh Dermot, Weinberger Daniel R, Sun Cuie, Flint Jonathan, Darvasi Ariel
Abstract excerpt
Sex differences in schizophrenia are well known, but their genetic basis has not been identified. We performed a genome-wide association scan for schizophrenia in an Ashkenazi Jewish population using DNA pooling. We found a female-specific association with rs7341475, a SNP in the fourth intron of the reelin (RELN) gene (p = 2.9 x 10(-5) in women), with a significant gene-sex effect (p = 1.8 x 10(-4)). We studied...
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