Article
Association study of RELN polymorphisms with schizophrenia in Han Chinese population.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Aug 2011
Li Wenqiang, Song Xueqin, Zhang Hongxing, Yang Yongfeng, Jiang Chengdi, Xiao Bo, Li Wei, Yang Ge, Zhao Jingyuan, Guo Weiyun, Lv Luxian
Abstract excerpt
Schizophrenia (SZ) is a common and complex psychiatric disorder with a strong genetic component. Previous research suggests that mutations altering genes in neurodevelopmental pathways contribute to SZ. Reelin gene (RELN) maps to chromosome 7q22.1, the encoded protein plays a pivotal role in guiding neuronal migration, lamination and connection during embryonic brain development. Several reports had indicated...
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