Post-transcriptional regulation of alpha-smooth muscle actin determines the contractile phenotype of Dupuytren's nodular cells.

doi:10.1002/jcp.22167

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Article

Post-transcriptional regulation of alpha-smooth muscle actin determines the contractile phenotype of Dupuytren's nodular cells.

Journal of cellular physiology - 1 Sept 2010

Verjee Liaquat Suleman, Midwood Kim, Davidson Dominique, Eastwood Mark, Nanchahal Jagdeep

Abstract excerpt

The objective was to study Dupuytren's myofibroblast cells in constrained collagen matrices in order to more closely emulate their in vivo environment and, to correlate their contractility with alpha-smooth muscle actin (alpha-SMA) expression and determine if dermal fibroblasts regulate Dupuytren's myofibroblast phenotype. Isotonic and isometric force contraction by cells isolated from Dupuytren's nodules, palmar...

Topics

Actins
Adult
Aged
Animals
Cells, Cultured
Coculture Techniques
Dupuytren Contracture
Fascia
Female
Fibroblasts
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Muscle Contraction

Muscle, Skeletal

Phenotype

Stress, Mechanical

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 20432463
DOI: 10.1002/jcp.22167

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