Article
Association of DRD2 variants and Gilles de la Tourette syndrome in a family-based sample from a South American population isolate.
Psychiatric genetics - 1 Aug 2010
Herzberg Ibi, Valencia-Duarte Ana Victoria, Kay Victoria A, White Daniel J, Müller Heike, Rivas Isabel C, Mesa Sandra Catalina, Cuartas Mauricio, García Jharley, Bedoya Gabriel, Cornejo William, Ruiz-Linares Andrés, Kremeyer Barbara
Abstract excerpt
Gilles de la Tourette Syndrome (GTS) is a chronic neuropsychiatric disorder characterized by motor and vocal tics. Epidemiological evidence supports the importance of genetic factors in disease susceptibility, whereas pharmacological and neuroimaging studies have suggested a defect in the dopamine system. The dopamine receptor D2 gene (DRD2) has been reported to be associated with GTS and related phenotypes....
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