Association of ADORA1 rs2228079 and ADORA2A rs5751876 Polymorphisms with Gilles de la Tourette Syndrome in the Polish Population.

doi:10.1371/journal.pone.0136754

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Article

Association of ADORA1 rs2228079 and ADORA2A rs5751876 Polymorphisms with Gilles de la Tourette Syndrome in the Polish Population.

PloS one - 1 Jan 2015

Janik Piotr, Berdyński Mariusz, Safranow Krzysztof, Żekanowski Cezary

Abstract excerpt

BACKGROUND: Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by motor and vocal tics. Hyperactivity of dopaminergic transmission is considered a prime abnormality in the pathophysiology of tics. There are reciprocal antagonistic interactions between adenosine and dopamine transmission. The aim of the study was to analyze the association of two polymorphisms, rs2228079 in ADORA1...

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PMID: 26317759
DOI: 10.1371/journal.pone.0136754
PMCID: PMC4552818

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ADORA1

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