Article
Bazooka is required for polarisation of the Drosophila anterior-posterior axis.
Development (Cambridge, England) - 1 May 2010
Doerflinger Hélène, Vogt Nina, Torres Isabel L, Mirouse Vincent, Koch Iris, Nüsslein-Volhard Christiane, St Johnston Daniel
Abstract excerpt
The Drosophila anterior-posterior (AP) axis is determined by the polarisation of the stage 9 oocyte and the subsequent localisation of bicoid and oskar mRNAs to opposite poles of the cell. Oocyte polarity has been proposed to depend on the same PAR proteins that generate AP polarity in C. elegans, with a complex of Bazooka (Baz; Par-3), Par-6 and aPKC marking the anterior and lateral cortex, and Par-1 defining...
Topics
- Alleles
- Animals
- Animals, Genetically Modified
- Body Patterning
- Cell Nucleus
- Cell Polarity
- Cytoskeleton
- Drosophila
- Drosophila Proteins
- Embryo, Nonmammalian
- Female
- Gene Expression Regulation, Developmental
- Glycogen Synthase Kinase 3