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Article

Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka.

Current biology : CB - 1 Jan 2000

Kuchinke U, Grawe F, Knust E

Abstract excerpt

BACKGROUND: The orientation of the mitotic spindle influences the asymmetric distribution of cytoplasmic determinants and the positioning of the sibling cell, and therefore has important influences on cell-fate determination and patterning of the embryo. Both the establishment of an axis of polarity and the adjustment of this axis with respect to the coordinates of the embryo have to be controlled. None of the...

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PMID: 9889099
DOI: 10.1016/s0960-9822(98)00016-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka.PMID 9889099Read ↗

Bazooka is required for polarisation of the Drosophila anterior-posterior axis.Semantic proximity Read ↗

Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.Semantic proximity Read ↗

Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts.Semantic proximity Read ↗

Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila.Semantic proximity Read ↗

Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the <i>Drosophila</i> ovarySemantic proximity Read ↗

Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts.Semantic proximity Read ↗

Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling.Semantic proximity Read ↗

The PAR proteins: fundamental players in animal cell polarization.Semantic proximity Read ↗

Requirement for Par-6 and Bazooka in Drosophila border cell migration.Semantic proximity Read ↗

Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions.Semantic proximity Read ↗

Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity.Semantic proximity Read ↗

Par‐3 family proteins in cell polarity & adhesionSemantic proximity Read ↗

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