AMY2A: a possible tumor-suppressor gene of 1p21.1 loss in gastric carcinoma.

Abstract excerpt

Homozygous deletions (HDs) are major genomic forces contributing to the development of many solid tumors. To identify critical tumor-suppressor loci involved in the pathogenesis of gastric carcinoma (GC), a high-resolution microarray-CGH was performed in a series of 27 GC patients. On a genome-wide profile, five distinct HD (log2 ratio <-1) loci, including 1p21.1, 2q21.1, 10q24.32, 13q34 and 15q11.2 were...

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