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Article

Integration of DNA Copy Number Alterations and Transcriptional Expression Analysis in Human Gastric Cancer

23 Apr 2012

Abstract excerpt

BACKGROUND: Genomic instability with frequent DNA copy number alterations is one of the key hallmarks of carcinogenesis. The chromosomal regions with frequent DNA copy number gain and loss in human gastric cancer are still poorly defined. It remains unknown how the DNA copy number variations contributes to the changes of gene expression profiles, especially on the global level. PRINCIPAL FINDINGS: We analyzed DNA...

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PMID: 22539939
DOI: 10.1371/journal.pone.0029824

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