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Application of second-generation sequencing to cancer genomics.

Briefings in bioinformatics - 1 Sept 2010

Robison Keith

Abstract excerpt

New generations of DNA sequencing technologies are enabling the systematic study of genetic derangement in cancers. Sequencing of cancer exomes or transcriptomes or even entire cancer genomes are now possible, though technical and economic challenges remain. Cancer samples are inherently heterogeneous and are often contaminated with normal DNA, placing additional demands on informatics tools for detecting genetic...

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PMID: 20427421
DOI: 10.1093/bib/bbq013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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