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Article

Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice.

The Journal of clinical investigation - 1 May 2010

Thomason Helen A, Zhou Huiqing, Kouwenhoven Evelyn N, Dotto Gian-Paolo, Restivo Gaia, Nguyen Bach-Cuc, Little Hayley, Dixon Michael J, van Bokhoven Hans, Dixon Jill

Abstract excerpt

Cleft palate is a common congenital disorder that affects up to 1 in 2,500 live human births and results in considerable morbidity to affected individuals and their families. The etiology of cleft palate is complex, with both genetic and environmental factors implicated. Mutations in the transcription factor-encoding genes p63 and interferon regulatory factor 6 (IRF6) have individually been identified as causes...

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Share to Cleft Palate
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Interferon Regulatory Factors

Share to Keratinocytes

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Share to Trans-Activators

Share to Transcriptional Activation

Source

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Identifiers

PMID: 20424327
DOI: 10.1172/JCI40266
PMCID: PMC2860913

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice.PMID 20424327Read ↗

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