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Article

Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf.

The EMBO journal - 8 Jul 2009

Su Xiaohua, Cho Min Soon, Gi Young-Jin, Ayanga Bernard A, Sherr Charles J, Flores Elsa R

Abstract excerpt

Mice lacking p63 cannot form skin, exhibit craniofacial and skeletal defects, and die soon after birth. The p63 gene regulates a complex network of target genes, and disruption of p63 has been shown to affect the maintenance of epithelial stem cells, the differentiation of keratinocytes, and the preservation of the adhesive properties of stratified epithelium. Here, we show that inactivation of p63 in mice is...

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Identifiers

PMID: 19494829
DOI: 10.1038/emboj.2009.151
PMCID: PMC2711186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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