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Article

p63 and IRF6: brothers in arms against cleft palate.

The Journal of clinical investigation - 1 May 2010

Gritli-Linde Amel

Abstract excerpt

Cleft lip and cleft palate, which can also occur together as cleft lip and palate, are frequent and debilitating congenital malformations, with complex geneses that have both genetic and environmental factors implicated. Mutations in the genes encoding the p53 homolog p63 and interferon regulatory factor 6 (IRF6) are major causes of cleft lip and cleft palate, but the molecular and cellular mechanisms underlying...

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Identifiers

PMID: 20424318
DOI: 10.1172/JCI42821
PMCID: PMC2860914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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