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Article

Functional characterization of vesicular excitatory amino acid transport by human sialin.

Journal of neurochemistry - 1 Oct 2011

Miyaji Takaaki, Omote Hiroshi, Moriyama Yoshinori

Abstract excerpt

Sialin, the protein coded by SLC17A5, is responsible for membrane potential (Δψ)-driven aspartate and glutamate transport into synaptic vesicles in addition to H+/sialic acid co-transport in lysosomes. Rodent sialin mutants harboring the mutations associated with Salla disease in humans did not transport aspartate and glutamate whereas H+/sialic acid co-transport activity was about one-third of the wild-type...

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PMID: 21781115
DOI: 10.1111/j.1471-4159.2011.07388.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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