Article
Homeostatic PPARα Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine
26 Apr 2016
Abstract excerpt
Dietary lipids and their metabolites activate members of the peroxisome proliferative-activated receptor (PPAR) family of transcription factors and are critical for colonic health. The PPARα isoform plays a vital role in regulating inflammation in various disease settings, but its role in intestinal inflammation, commensal homeostasis, and mucosal immunity in the gut are unclear. In this study, we demonstrate...
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