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Article

Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation.

Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2010

Rowbotham Sophie E, Boddy Alan V, Redfern Chris P F, Veal Gareth J, Daly Ann K

Abstract excerpt

CYP2C8 has a major role in the metabolism of the anticancer agents 13-cis retinoic acid (13cisRA) and paclitaxel. There is evidence that polymorphisms in the CYP2C8 gene contribute to observed interindividual differences in paclitaxel metabolism. However, no studies have been performed to determine the relevance of CYP2C8 polymorphisms to 13cisRA metabolism. In the current study, the effect of two common...

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Source

Identifiers

PMID: 20421446
DOI: 10.1124/dmd.109.030866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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