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Bipolar disorder

5 Apr 2012

Abstract excerpt

Cytochrome P450 (CYP) 2C8 has a major role in the metabolism of the anticancer agents 13-<i>cis</i> retinoic acid (13<i>cis</i>RA) and paclitaxel. There is evidence that polymorphisms in the CYP2C8 gene contribute to observed inter-individual differences in paclitaxel metabolism. However, no studies have been performed to determine the relevance of CYP2C8 polymorphisms to 13<i>cis</i>RA metabolism. In the current...

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PMID: 23271744
DOI: 10.1136/bmj.e8508

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