Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes.

Biochemical pharmacology - 1 Dec 2002

Bahadur Namrata, Leathart Julian B S, Mutch Elaine, Steimel-Crespi Dorothy, Dunn Stuart A, Gilissen Ron, Houdt Jos Van, Hendrickx Jan, Mannens Geert, Bohets Hilde, Williams Faith M, Armstrong Martin, Crespi Charles L, Daly Ann K

Abstract excerpt

Published cDNA sequences suggest the existence of non-synonymous single nucleotide polymorphisms in the cytochrome P450 CYP2C8. To determine whether these polymorphisms could be confirmed in a Caucasian population and to investigate whether additional polymorphisms occur in the coding and upstream regions of this gene, we screened for previously described and for novel polymorphisms using PCR-RFLP and SSCP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Hydroxylases
Share to Cytochrome P-450 CYP2C8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to Microsomes, Liver

Share to Paclitaxel

Share to Polymorphism, Single-Stranded Conformational

Share to Sequence Homology, Amino Acid

Share to White People

Source

Identifiers

PMID: 12429347
DOI: 10.1016/s0006-2952(02)01354-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes.PMID 12429347Read ↗

Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism.Semantic proximity Read ↗

Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism.Semantic proximity Read ↗

Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population.Semantic proximity Read ↗

Functional characterization of five CYP2C8 variants and prediction of CYP2C8 genotype-dependent effects on in vitro and in vivo drug-drug interactions.Semantic proximity Read ↗

Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.Semantic proximity Read ↗

CYP2C8 polymorphism among the Portuguese.Semantic proximity Read ↗

Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies.Semantic proximity Read ↗

Prevalence of CYP2C8 polymorphisms in a North Indian population.Semantic proximity Read ↗

Genetic polymorphisms of CYP2C8 in the Czech Republic.Semantic proximity Read ↗

Identification of new CYP2C19 variants exhibiting decreased enzyme activity in the metabolism of S-mephenytoin and omeprazole.Semantic proximity Read ↗

Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation.Semantic proximity Read ↗

Genetic polymorphism in exon 4 of cytochrome P450 CYP2C9 may be associated with warfarin sensitivity in Chinese patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.