Article
Somatic hypermutation profiles in stereotyped IGHV4-34 receptors from South American chronic lymphocytic leukemia patients.
Annals of hematology - 1 Feb 2022
Stanganelli Carmen, Torres Davi Coe, Ortega Claudia, Márquez María Elena, Remedi Victoria, Cabrera Juana, Mardaraz Claudia, Galvano Camila, Krzywinski Andrea, Lang Cecilia, Zanella Lorena, Agriello Evangelina, Bezares Raimundo, Pavlovsky Astrid, Pavlovsky Miguel A, Oppezzo Pablo, Slavutsky Irma
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is the most common mature B-cell neoplasm in the West. IGHV4-34 is one of the most frequently used genes in CLL patients, which usually display an indolent outcome. In this study, we explored the mutational profile of CLL patients expressing IGHV4-34 within different stereotypes and their association with prognostic factors and clinical outcome. A multi-institutional cohort of...
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