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Article

Genetic Lesions in Russian CLL Patients with the Most Common Stereotyped Antigen Receptors.

Genes - 20 Feb 2023

Biderman Bella V, Likold Ekaterina B, Severina Nataliya A, Obukhova Tatiana N, Sudarikov Andrey B

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is one of the most common B-cell malignancies in Western countries. IGHV mutational status is the most important prognostic factor for this disease. CLL is characterized by an extreme narrowing of the IGHV genes repertoire and the existence of subgroups of quasi-identical stereotyped antigenic receptors (SAR). Some of these subgroups have already been identified as independent...

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Share to B-Lymphocytes
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Identifiers

PMID: 36833459
DOI: 10.3390/genes14020532
PMCID: PMC9957161

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