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Article

Disruption of lysosome function promotes tumor growth and metastasis in Drosophila.

The Journal of biological chemistry - 9 Jul 2010

Chi Congwu, Zhu Huanhu, Han Min, Zhuang Yuan, Wu Xiaohui, Xu Tian

Abstract excerpt

Lysosome function is essential to many physiological processes. It has been suggested that deregulation of lysosome function could contribute to cancer. Through a genetic screen in Drosophila, we have discovered that mutations disrupting lysosomal degradation pathway components contribute to tumor development and progression. Loss-of-function mutations in the Class C vacuolar protein sorting (VPS) gene, deep...

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Identifiers

PMID: 20418542
DOI: 10.1074/jbc.M110.131714
PMCID: PMC2898421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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