Article
Quantification of periciliary fluid height in human airway biopsies is feasible, but not suitable as a biomarker.
American journal of respiratory cell and molecular biology - 1 Mar 2011
Griesenbach Uta, Soussi Samia, Larsen Mia B, Casamayor Isabel, Dewar Ann, Regamey Nicolas, Bush Andrew, Shah Pallav L, Davies Jane C, Alton Eric W F W
Abstract excerpt
The "low volume hypothesis," stating that imbalanced ion movement across the cystic fibrosis (CF) airway epithelium leads to a reduction in periciliary fluid (PCL) and consequently impaired mucociliary clearance, has been the prevailing theory explaining CF pathophysiology, and has been supported by animal models and ex vivo cell culture systems. However, studies in freshly obtained human tissue have not yet been...
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