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Multidrug resistance in oral squamous cell carcinoma: The role of vacuolar ATPases

26 Apr 2010

Abstract excerpt

Resistance to chemotherapy agents is the main reason for treatment failure in patients with cancer. Multidrug resistance (MDR) is the primary mechanism that leads to the acquisition of the multiresistant phenotype through the overexpression of drug efflux transporters such as the P-glycoprotein (Pgp), encoded by the MDR1 gene, at the plasma membrane. Other molecules that have been implicated in drug resistance...

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PMID: 20418015
DOI: 10.1016/j.canlet.2010.03.019

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