Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down‐regulating the V‐ATPases/mTOR/HIF‐1α/P‐gp and MRP1 signaling pathway in vitro and in vivo

Abstract excerpt

To investigate reversal effects of pantoprazole (PPZ) on multidrug resistance (MDR) in human gastric adenocarcinoma cells in vivo and in vitro. Human gastric adenocarcinoma cell SGC7901 was cultured in RPMI-1640 medium supplemented with 10% fetal bovine serum and antibiotics in a humidified 5% CO(2) atmosphere at 37°C. Adriamycin (ADR)-resistant cells were cultured with addition of 0.8 µg/ml of ADR maintaining...

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