Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A simple method of investigating mutations in CHEK2 by DHPLC: a study of the German populations of Saxony, Saxony-Anhalt, and Thuringia.

Cancer genetics and cytogenetics - 1 May 2010

Scharrer Ulrike, Skrzypczak-Zielinska Marzena, Wituszynska Weronika, Mierzejewski Marek, Krause Kristin, Cybulski Cezary, Froster Ursula G

Abstract excerpt

Allele variants of the CHEK2 gene have been found to be associated with several types of cancer, including cancer of the breast, prostate, lung, and ovary. In the Polish population, three founder mutations of CHEK2 have been identified: I157T, 444+1G>A (formerly IVS2+1G>A), and 1100delC. The aim of our study was to establish a simple method to identify founder CHEK2 mutations and determine the prevalence of these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Checkpoint Kinase 2
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Genetics, Population

Share to Germany

Share to Homozygote

Share to Nucleic Acid Denaturation

Share to Protein Serine-Threonine Kinases

Source

Identifiers

PMID: 20417869
DOI: 10.1016/j.cancergencyto.2009.11.015

Genes

CHEK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A simple method of investigating mutations in CHEK2 by DHPLC: a study of the German populations of Saxony, Saxony-Anhalt, and Thuringia.PMID 20417869Read ↗

A deletion in CHEK2 of 5,395 bp predisposes to breast cancer in Poland.Semantic proximity Read ↗

CHEK2 c.1100delC allele is rarely identified in Greek breast cancer cases.Semantic proximity Read ↗

German populations with infrequent CHEK2*1100delC and minor associations with early-onset and familial breast cancer.Semantic proximity Read ↗

Association of two mutations in the CHEK2 gene with breast cancer.Semantic proximity Read ↗

Limited relevance of the CHEK2 gene in hereditary breast cancer.Semantic proximity Read ↗

Increased Risk for Other Cancers in Addition to Breast Cancer for CHEK2*1100delC Heterozygotes Estimated From the Copenhagen General Population Study.Semantic proximity Read ↗

Frequency of the CHEK2 1100delC mutation among women with breast cancer: an international study.Semantic proximity Read ↗

The CHEK2 c.1100delC germline mutation rarely contributes to breast cancer development in the Czech RepublicSemantic proximity Read ↗

The risk of gastric cancer in carriers of CHEK2 mutations.Semantic proximity Read ↗

Missense mutations (p.H371Y, p.D438Y) in gene CHEK2 are associated with breast cancer risk in women of Balochistan origin.Semantic proximity Read ↗

A search for modifying genetic factors in CHEK2:c.1100delC breast cancer patients.Semantic proximity Read ↗

A novel founder CHEK2 mutation is associated with increased prostate cancer risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.