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Article

Vaccination with a Leishmania infantum HSP70-II null mutant confers long-term protective immunity against Leishmania major infection in two mice models.

PLoS neglected tropical diseases - 1 May 2017

Solana José Carlos, Ramírez Laura, Corvo Laura, de Oliveira Camila Indiani, Barral-Netto Manoel, Requena José María, Iborra Salvador, Soto Manuel

Abstract excerpt

BACKGROUND: The immunization with genetically attenuated Leishmania cell lines has been associated to the induction of memory and effector T cell responses against Leishmania able to control subsequent challenges. A Leishmania infantum null mutant for the HSP70-II genes has been described, possessing a non-virulent phenotype. METHODOLOGY/PRINCIPAL FINDINGS: The L. infantum attenuated parasites (LiΔHSP70-II) were...

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Identifiers

PMID: 28558043
DOI: 10.1371/journal.pntd.0005644
PMCID: PMC5466331

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