Article
Multiplexed electrochemical DNA sensor for single-nucleotide polymorphism typing by using oligonucleotide-incorporated nonfouling surfaces.
The journal of physical chemistry. B - 20 May 2010
Wan Ying, Lao Ruojun, Liu Gang, Song Shiping, Wang Lihua, Li Di, Fan Chunhai
Abstract excerpt
In this work, we report a multiplexed electrochemical DNA sensor for highly specific single-nucleotide polymorphism (SNP) detection by using oligonucleotide-incorporated nonfouling surfaces (ONS). A typical "sandwich" scheme was employed to perform the SNP assay. The presence of the target DNA templated the ligation between the capture probe DNA anchored on gold electrodes and the tandem reporter probe tagged...
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